including tuberculosis. serious and sometimes fatal events can occur, such as infections, cancer in children and adults, heart failure, nervous system disorders, liver or blood problems, and allergic reactions. before starting simponi™, your doctor should test you for tb and assess your risk of infections, including fungal infections and hepatitis b. ask your doctor if you've been to a region where certain fungal infections are common. tell your doctor if you're prone to infections, or develop symptoms such as fever, fatigue, cough, or sores. you should not start simponi™ if you have an infection. [ female announcer ] ask your rheumatologist about simponi™. just one dose, once a month.